Britain launches COVID-19 vaccine study

Testing of an experimental COVID-19 vaccine began in healthy volunteers in Britain Thursday, the latest in a cluster of early-stage studies in search of protection against the coronavirus.

University of Oxford researchers gave injections to volunteers in a study that eventually aims to include hundreds in hopes of telling not only if the vaccine is safe but if it works.

Researchers created the new vaccine by inserting genes for a spikey protein that studs the outer surface of the new coronavirus into another, harmless virus.

The idea: The immune system will spot the foreign protein and make antibodies to fight it, primed to react quickly if the person eventually is exposed to COVID-19.

These kinds of studies often give volunteers either the real vaccine or a dummy shot.

But this experimental vaccine may briefly cause soreness and maybe a low fever — meaning if a dummy shot was the comparison, the participants might figure out who got the real thing, said Dr Andrew Pollard, one of the Oxford chief researchers.

“That might influence people’s behaviour, perhaps make them more likely to be exposed to the virus,” which in turn would make it harder to prove if the vaccine worked, Pollard told The Associated Press.

So the Oxford team decided half the volunteers will be given an old vaccine against another disease that offers no COVID-19 protection but has similar shot side effects.

“It seems like the right thing to do — to ensure that we can combat this disease and get over it a lot faster,” volunteer Edward O’Neill told the BBC afterward.

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